Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis.

Gelatinase B/matrix metalloproteinase-9 (MMP-9) triggers multiple sclerosis (MS) and the animal model of experimental autoimmune encephalomyelitis (EAE) by the breakdown of the blood-brain barrier. Interestingly, MMP-9 is beneficial in systemic autoimmunity caused by Fas-deficiency. Fas-deficient (f...

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Main Authors: Estefania Ugarte-Berzal, Nele Berghmans, Lise Boon, Erik Martens, Jennifer Vandooren, Bénédicte Cauwe, Greet Thijs, Paul Proost, Jo Van Damme, Ghislain Opdenakker
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2018-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC6166937?pdf=render
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