Imatinib and Dasatinib Provoke Mitochondrial Dysfunction Leading to Oxidative Stress in C2C12 Myotubes and Human RD Cells

Tyrosine kinase inhibitors (TKIs) can cause skeletal muscle toxicity in patients, but the underlying mechanisms are mostly unclear. The goal of the current study was to better characterize the role of mitochondria in TKI-associated myotoxicity. We exposed C2C12 murine myoblasts and myotubes as well...

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Hauptverfasser: Jamal Bouitbir, Miljenko Valentin Panajatovic, Theo Frechard, Noëmi Johanna Roos, Stephan Krähenbühl
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020-07-01
Schriftenreihe:Frontiers in Pharmacology
Schlagworte:
imatinib
dasatinib
myotoxicity
electron transport chain (ETC)
reactive oxygen species (ROS)
apoptosis
Online Zugang:https://www.frontiersin.org/article/10.3389/fphar.2020.01106/full
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