Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1

Decreased serum adiponectin levels in type 2 diabetes has been linked to the onset of mitochondrial dysfunction in diabetic complications by impairing AMPK-SIRT1-PGC-1α signaling via impaired adiponectin receptor 1 (AdipoR1) signaling. Here, we aimed to characterize the previously undefined role of...

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Main Authors: Mark E. Pepin, Christoph Koentges, Katharina Pfeil, Johannes Gollmer, Sophia Kersting, Sebastian Wiese, Michael M. Hoffmann, Katja E. Odening, Constantin von zur Mühlen, Philipp Diehl, Peter Stachon, Dennis Wolf, Adam R. Wende, Christoph Bode, Andreas Zirlik, Heiko Bugger
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019-12-01
Serija:Frontiers in Endocrinology
Teme:
mitochondria
adiponectin
adiponectin receptor
diabetes
heart
proteome
Online dostop:https://www.frontiersin.org/article/10.3389/fendo.2019.00872/full
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