Nigrostriatal Dopaminergic Denervation Does Not Promote Impulsive Choice in the Rat: Implication for Impulse Control Disorders in Parkinson’s Disease

Impulse control disorders (ICDs) are frequent behavioral complications of dopaminergic (DA) replacement therapies (DRTs) in Parkinson’s disease (PD). Impulsive choice, which refers to an inability to tolerate delays to reinforcement, has been identified as a core pathophysiological process of ICDs....

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Detalhes bibliográficos
Main Authors: Robin Magnard, Yvan Vachez, Carole Carcenac, Sabrina Boulet, Jean-Luc Houeto, Marc Savasta, David Belin, Sebastien Carnicella
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-12-01
Colecção:Frontiers in Behavioral Neuroscience
Assuntos:
Parkinson’s disease
impulse control disorders
impulsive choice
delay discounting task
dopaminergic nigrostriatal system
6-OHDA
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnbeh.2018.00312/full
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