1,2,3-Triazole β-lactam conjugates as antimicrobial agents

A convenient and efficient synthesis of new triazole β-lactam conjugates using click chemistry is described. β-lactam 15 and 16 were prepared using cycloaddition strategy and propargylated at N-1 to afford compounds 17 and 18. Cu-catalyzed click reaction of these β-lactams 17 and 18 with different a...

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Main Authors: Rajneesh Kaur, Raman Singh, Antresh Kumar, Satvinder Kaur, Nitesh Priyadarshi, Nitin Kumar Singhal, Kuldeep Singh
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020-06-01
Series:Heliyon
Assuntos:
Pharmaceutical chemistry
Microbiology
Triazole
Beta-lactam
Conjugates
Antibacterial assay
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2405844020310859
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