Functional Phenotypes of Peritoneal Macrophages Upon AMD3100 Treatment During Colitis-Associated Tumorigenesis

CXCL12 and its receptor CXCR4 are independent prognostic factors in colorectal cancer. AMD3100 is the most frequently used FDA-approved antagonist that targets the CXCL12-CXCR4 axis in clinical trials. We aimed to explore the role of AMD3100 and its effect on peritoneal macrophages' functional...

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Main Authors: Shuai Wu, Weiwei Luo, Xing Wu, Zhaohua Shen, Xiaoyan Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Medicine
Assuntos:
colorectal cancer
tumorigenesis
CXCL12
AMD3100
peritoneal macrophages
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmed.2022.840704/full
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