ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma

Abstract Background Increasing evidence support an important role for DNA methylation in nasopharyngeal carcinoma (NPC). Here, we explored the role of circadian clock gene Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) methylation in NPC. Methods We employed bisulfite pyrosequencing to...

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Detaylı Bibliyografya
Asıl Yazarlar: Hao Peng, Jian Zhang, Pan-Pan Zhang, Lei Chen, Ling-Long Tang, Xiao-Jing Yang, Qing-Mei He, Xin Wen, Ying Sun, Na Liu, Ying-Qin Li, Jun Ma
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2019-01-01
Seri Bilgileri:Journal of Experimental & Clinical Cancer Research
Konular:
Nasopharyngeal carcinoma
ARNTL
Methylation
Proliferation
CDK5
Chemotherapy sensitivity
Online Erişim:http://link.springer.com/article/10.1186/s13046-018-0997-7
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