ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma

Abstract Background Increasing evidence support an important role for DNA methylation in nasopharyngeal carcinoma (NPC). Here, we explored the role of circadian clock gene Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) methylation in NPC. Methods We employed bisulfite pyrosequencing to...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Hao Peng, Jian Zhang, Pan-Pan Zhang, Lei Chen, Ling-Long Tang, Xiao-Jing Yang, Qing-Mei He, Xin Wen, Ying Sun, Na Liu, Ying-Qin Li, Jun Ma
Format: Artigo
Langue:Inglês
Publié: BMC 2019-01-01
Collection:Journal of Experimental & Clinical Cancer Research
Sujets:
Nasopharyngeal carcinoma
ARNTL
Methylation
Proliferation
CDK5
Chemotherapy sensitivity
Accès en ligne:http://link.springer.com/article/10.1186/s13046-018-0997-7
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