Evolution of resistance mechanisms and biological characteristics of rifampicin-resistant Staphylococcus aureus strains selected in vitro

Abstract Background We aimed to determine the evolutionary pathways of rifampicin resistance in Staphylococcus aureus, and the impact of resistance mutations in the rpoB gene on fitness. Methods Three clinical strains and one reference strain were used to select for rifampicin-resistant S. aureus va...

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Main Authors: Chong Wang, Renchi Fang, Beibei Zhou, Xuebin Tian, Xiucai Zhang, Xiangkuo Zheng, Siqin Zhang, Guofeng Dong, Jianming Cao, Tieli Zhou
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-09-01
Colecção:BMC Microbiology
Assuntos:
Staphylococcus aureus
Rifampicin resistance
Drug resistance evolution
Fitness cost
Acesso em linha:http://link.springer.com/article/10.1186/s12866-019-1573-9
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