Increase in Ca2+-Activated cAMP/PKA Signaling Prevents Hydroxychloroquine-Induced Bradycardia of the Cardiac Pacemaker

Bradycardia or tachycardia are known side effects of drugs that limit their clinical use. The heart pacemaker function which control the heart rate under normal conditions is determined by coupled clock system. Thus, interfering with specific clock mechanism will affect other clock mechanisms throug...

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Main Authors: Sofia Segal, Limor Arbel-Ganon, Savyon Mazgaoker, Moran Davoodi, Yael Yaniv
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2022-05-01
Serija:Frontiers in Physiology
Teme:
hydroxychloroquine
COVID-19
IBMX
pacemaker
phosphodiesterase inhibition
Online dostop:https://www.frontiersin.org/articles/10.3389/fphys.2022.839140/full
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