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Xanthohumol inhibits Notch signaling and induces apoptosis in hepatocellular carcinoma.

Despite improvement in therapeutic strategies, median survival in advanced hepatocellular carcinoma (HCC) remains less than one year. Therefore, molecularly targeted compounds with less toxic profiles are needed. Xanthohumol (XN), a prenylated chalcone has been shown to have anti-proliferative effec...

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Detalhes bibliográficos
Main Authors: Selvi Kunnimalaiyaan, Kevin M Sokolowski, Mariappan Balamurugan, T Clark Gamblin, Muthusamy Kunnimalaiyaan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2015-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC4444108?pdf=render
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