Hypoxia-preconditioned mesenchymal stem cells prevent renal fibrosis and inflammation in ischemia-reperfusion rats

Abstract Background Mesenchymal stem cells (MSCs) have been reported to promote the regeneration of injured tissue via their paracrine abilities, which are enhanced by hypoxic preconditioning. In this study, we examined the therapeutic efficacy of hypoxia-preconditioned MSCs on renal fibrosis and in...

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Main Authors: Naoki Ishiuchi, Ayumu Nakashima, Shigehiro Doi, Ken Yoshida, Satoshi Maeda, Ryo Kanai, Yumi Yamada, Takeshi Ike, Toshiki Doi, Yukio Kato, Takao Masaki
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-03-01
Colecção:Stem Cell Research & Therapy
Assuntos:
Mesenchymal stem cells
Hypoxia
Vascular endothelial growth factor
Hepatocyte growth factor
Renal fibrosis
Acesso em linha:http://link.springer.com/article/10.1186/s13287-020-01642-6
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