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Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington's Disease T Lymphocytes.

Huntington's disease is a fatal neurodegenerative condition caused by a CAG repeat expansion in the huntingtin gene. The peripheral innate immune system is dysregulated in Huntington's disease and may contribute to its pathogenesis. However, it is not clear whether or to what extent the ad...

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Auteurs principaux: James R C Miller, Ulrike Träger, Ralph Andre, Sarah J Tabrizi
Format: Artigo
Langue:Inglês
Publié: Public Library of Science (PLoS) 2015-01-01
Collection:PLoS ONE
Accès en ligne:http://europepmc.org/articles/PMC4631523?pdf=render
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