Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects

Abstract Background To investigate the effects of coadministration of esaxerenone with amlodipine on the pharmacokinetics (PK) of each drug, and of esaxerenone on the PK of digoxin. Methods In three open-label, single-sequence, crossover studies, healthy Japanese males received single oral doses of...

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Main Authors: Yoshiaki Kirigaya, Masanari Shiramoto, Tomoko Ishizuka, Hinako Uchimaru, Shin Irie, Manabu Kato, Takako Shimizu, Takafumi Nakatsu, Yasuhiro Nishikawa, Hitoshi Ishizuka
Format: Artigo
Language:Inglês
Published: BMC 2020-07-01
Series:BMC Pharmacology and Toxicology
Subjects:
Esaxerenone
Drug interactions
Pharmacokinetics
Digoxin
Amlodipine
Online Access:http://link.springer.com/article/10.1186/s40360-020-00423-4
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