Inhibition of Heme Oxygenase-1 by Zinc Protoporphyrin IX Improves Adverse Pregnancy Outcomes in Malaria During Early Gestation

The enzyme heme oxygenase-1 (HO-1) has cytoprotective effects by catalyzing the degradation of heme to produce carbon monoxide, iron and biliverdin. Furthermore, HO-1 activity has been associated with successful pregnancy. On the other hand, in the context of certain inflammatory conditions, HO-1 ca...

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Main Authors: Yusmaris Cariaco, Marcos Paulo Oliveira Almeida, Ester Cristina Borges Araujo, Marisol Patricia Pallete Briceño, Andrea Tatiana Durán-Rodriguez, Rodrigo Rodrigues Franco, Foued Salmen Espindola, Neide Maria Silva
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Immunology
Assuntos:
HO-1
malaria
pregnancy
uterine natural killer cells
iron overload
ferroptosis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.879158/full
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