TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity.

Insulin/IGF-1 signaling plays a pivotal role in the regulation of cellular homeostasis through its control of glucose metabolism as well as due to its effects on cell proliferation. Aberrant regulation of insulin signaling has been repeatedly implicated in uncontrolled cell growth and malignant tran...

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Bibliographic Details
Main Authors: Marisa J Wainszelbaum, Jialu Liu, Chen Kong, Priya Srikanth, Dmitri Samovski, Xiong Su, Philip D Stahl
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3278430?pdf=render
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