Kynurenine Promotes RANKL–Induced Osteoclastogenesis In Vitro by Activating the Aryl Hydrocarbon Receptor Pathway

There is increasing evidence of the involvement of the tryptophan metabolite kynurenine (KYN) in disrupting osteogenesis and contributing to aging-related bone loss. Here, we show that KYN has an effect on bone resorption by increasing osteoclastogenesis. We have previously reported that in vivo tre...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Nada H. Eisa, Sakamuri V. Reddy, Ahmed M. Elmansi, Galina Kondrikova, Dmitry Kondrikov, Xing-Ming Shi, Chad M. Novince, Mark W. Hamrick, Meghan E. McGee-Lawrence, Carlos M. Isales, Sadanand Fulzele, William D. Hill
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI AG 2020-10-01
Серии:International Journal of Molecular Sciences
Предметы:
Kynurenine
AhR
osteoclast
NFATc1
c-fos
Online-ссылка:https://www.mdpi.com/1422-0067/21/21/7931
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы