Kynurenine Promotes RANKL–Induced Osteoclastogenesis In Vitro by Activating the Aryl Hydrocarbon Receptor Pathway

There is increasing evidence of the involvement of the tryptophan metabolite kynurenine (KYN) in disrupting osteogenesis and contributing to aging-related bone loss. Here, we show that KYN has an effect on bone resorption by increasing osteoclastogenesis. We have previously reported that in vivo tre...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nada H. Eisa, Sakamuri V. Reddy, Ahmed M. Elmansi, Galina Kondrikova, Dmitry Kondrikov, Xing-Ming Shi, Chad M. Novince, Mark W. Hamrick, Meghan E. McGee-Lawrence, Carlos M. Isales, Sadanand Fulzele, William D. Hill
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI AG 2020-10-01
Cyfres:International Journal of Molecular Sciences
Pynciau:
Kynurenine
AhR
osteoclast
NFATc1
c-fos
Mynediad Ar-lein:https://www.mdpi.com/1422-0067/21/21/7931
Tagiau: Ychwanegu Tag
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