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HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly.
Sonic Hedgehog/GLI3 signaling is critical in regulating digit number, such that Gli3-deficiency results in polydactyly and Shh-deficiency leads to digit number reductions. SHH/GLI3 signaling regulates cell cycle factors controlling mesenchymal cell proliferation, while simultaneously regulating Grem...
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| Hoofdauteurs: | , , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science (PLoS)
2021-12-01
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| Reeks: | PLoS Genetics |
| Online toegang: | https://doi.org/10.1371/journal.pgen.1009982 |
| Tags: |
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