Secondary Complement Deficiency Impairs Anti-Microbial Immunity to Klebsiella pneumoniae and Staphylococcus aureus During Severe Acute COVID-19

A high incidence of secondary Klebsiella pneumoniae and Staphylococcus aureus infection were observed in patients with severe COVID-19. The cause of this predisposition to infection is unclear. Our data demonstrate consumption of complement in acute COVID-19 patients reflected by low levels of C3, C...

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Main Authors: Youssif M. Ali, Nicholas J. Lynch, Priyanka Khatri, Ifeoluwa E. Bamigbola, Andrew C. Y. Chan, Munehisa Yabuki, Gregory A. Demopulos, Jonathan L. Heeney, Sumita Pai, Helen Baxendale, Wilhelm J. Schwaeble
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Immunology
Assuntos:
K. pneumoniae
COVID-19
SARS-CoV-2
complement system
bacterial infection
S. aureus
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.841759/full
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