Citrate Mediates Crosstalk between Mitochondria and the Nucleus to Promote Human Mesenchymal Stem Cell In Vitro Osteogenesis

Citrate, generated in the mitochondria, is a key metabolite that might link metabolism with signaling, chromatin structure and transcription to orchestrate mesenchymal stem cells (MSCs) fate determination. Based on a detailed morphological analysis of 3D reconstruction of mitochondria and nuclei in...

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Main Authors: Claudia Morganti, Massimo Bonora, Saverio Marchi, Letizia Ferroni, Chiara Gardin, Mariusz R. Wieckowski, Carlotta Giorgi, Paolo Pinton, Barbara Zavan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-04-01
Serier:Cells
Fag:
osteogenesis
citrate
α-ketoglutarate
mitochondrial metabolism
mesenchymal stem cells
mitochondria-nucleus communication
Online adgang:https://www.mdpi.com/2073-4409/9/4/1034
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