Using the Minor Variant Finder software to identify and quantify the allelic burden level of somatic mutations in oncohematologic diseases

Background. There are problems related to both quantitative assessment of an allele burden level of a mutant gene and interpretation of results in DNA samples with the burden level of the mutant allele less than 15–20 %, when using Sanger sequencing for analyzing somatic mutations. Applied Biosystem...

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Main Authors: T. N. Subbotina, I. E. Maslyukova, A. A. Faleeva, P. A. Nikolaeva, A. S. Khazieva, E. A. Dunaeva, K. O. Mironov, L. B. Polushkina, I. S. Martynkevich, S. V. Vereshchagina, B. V. Barankin
Formato: Artigo
Idioma:Russo
Publicado em: ABV-press 2020-07-01
Colecção:Onkogematologiâ
Assuntos:
minor variant finder
asxl1
jak2
bcr-abl
myeloproliferative neoplasm
ph-myeloproliferative neoplasm
chronic myeloid leukemia
Acesso em linha:https://oncohematology.abvpress.ru/ongm/article/view/421
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