Rac1 GTPase Inhibition Blocked Podocyte Injury and Glomerular Sclerosis during Hyperhomocysteinemia via Suppression of Nucleotide-Binding Oligomerization Domain-Like Receptor Containing Pyrin Domain 3 Inflammasome Activation

Elevated homocysteine (Hcy) levels have been shown to activate nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome leading to podocyte dysfunction and glomerular injury. However, it remains unclear how this inflammasome activation in podocytes is a...

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Main Authors: Qinghua Zhang, Sabena M. Conley, Guangbi Li, Xinxu Yuan, Pin-Lan Li
Formato: Artigo
Idioma:Inglês
Publicado em: Karger Publishers 2019-07-01
Colecção:Kidney & Blood Pressure Research
Assuntos:
Rac1 GTPase
Membrane rafts
Inflammatory machinery
Glomerulosclerosis
Reactive oxygen species
Acesso em linha:https://www.karger.com/Article/FullText/500457
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