De novo identification of maximally deregulated subnetworks based on multi-omics data with DeRegNet

Abstract Background With a growing amount of (multi-)omics data being available, the extraction of knowledge from these datasets is still a difficult problem. Classical enrichment-style analyses require predefined pathways or gene sets that are tested for significant deregulation to assess whether t...

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Detalhes bibliográficos
Main Authors: Sebastian Winkler, Ivana Winkler, Mirjam Figaschewski, Thorsten Tiede, Alfred Nordheim, Oliver Kohlbacher
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:BMC Bioinformatics
Assuntos:
Biomolecular networks
Fractional integer programming
De-novo subnetwork enrichment
Functional enrichment
Omics data
Acesso em linha:https://doi.org/10.1186/s12859-022-04670-6
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