A Statistical Method for Observing Personal Diploid Methylomes and Transcriptomes with Single-Molecule Real-Time Sequencing

We address the problem of observing personal diploid methylomes, CpG methylome pairs of homologous chromosomes that are distinguishable with respect to phased heterozygous variants (PHVs), which is challenging due to scarcity of PHVs in personal genomes. Single molecule real-time (SMRT) sequencing i...

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Bibliographic Details
Main Authors: Yuta Suzuki, Yunhao Wang, Kin Fai Au, Shinichi Morishita
Format: Artigo
Language:Inglês
Published: MDPI AG 2018-09-01
Series:Genes
Subjects:
statistical methods
DNA methylation
gene expression
single molecule real-time sequencing
allele-specific analysis
Online Access:http://www.mdpi.com/2073-4425/9/9/460
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