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Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors.

The presence of replication-competent HIV-1 -which resides mainly in resting CD4+ T cells--is a major hurdle to its eradication. While pharmacological approaches have been useful for inducing the expression of this latent population of virus, they have been unable to purge HIV-1 from all its reservo...

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Detalhes bibliográficos
Main Authors: Pedro Perdigão, Thomas Gaj, Mariana Santa-Marta, Carlos F Barbas, Joao Goncalves
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2016-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC4774903?pdf=render
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