A Systematic, Unbiased Mapping of CD8+ and CD4+ T Cell Epitopes in Yellow Fever Vaccinees

Examining CD8+ and CD4+ T cell responses after primary Yellow Fever vaccination in a cohort of 210 volunteers, we have identified and tetramer-validated 92 CD8+ and 50 CD4+ T cell epitopes, many inducing strong and prevalent (i.e., immunodominant) T cell responses. Restricted by 40 and 14 HLA-class...

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Main Authors: Anette Stryhn, Michael Kongsgaard, Michael Rasmussen, Mikkel Nors Harndahl, Thomas Østerbye, Maria Rosaria Bassi, Søren Thybo, Mette Gabriel, Morten Bagge Hansen, Morten Nielsen, Jan Pravsgaard Christensen, Allan Randrup Thomsen, Soren Buus
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-08-01
Colecção:Frontiers in Immunology
Assuntos:
yellow fever vaccination
immunogenicity
CD4+ and CD8+ T cell epitope discovery
forward-reverse immunology
immunodominance and immunodomination
peptide-MHC tetramers
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2020.01836/full
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