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Differential methylation analysis of reduced representation bisulfite sequencing experiments using edgeR [version 1; referees: 2 approved, 1 approved with reservations]

Studies in epigenetics have shown that DNA methylation is a key factor in regulating gene expression. Aberrant DNA methylation is often associated with DNA instability, which could lead to development of diseases such as cancer. DNA methylation typically occurs in CpG context. When located in a gene...

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Autori principali: Yunshun Chen, Bhupinder Pal, Jane E. Visvader, Gordon K. Smyth
Natura: Artigo
Lingua:Inglês
Pubblicazione: F1000 Research Ltd 2017-11-01
Serie:F1000Research
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Accesso online:https://f1000research.com/articles/6-2055/v1
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