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Differential methylation analysis of reduced representation bisulfite sequencing experiments using edgeR [version 1; referees: 2 approved, 1 approved with reservations]

Studies in epigenetics have shown that DNA methylation is a key factor in regulating gene expression. Aberrant DNA methylation is often associated with DNA instability, which could lead to development of diseases such as cancer. DNA methylation typically occurs in CpG context. When located in a gene...

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Main Authors: Yunshun Chen, Bhupinder Pal, Jane E. Visvader, Gordon K. Smyth
Formato: Artigo
Idioma:Inglês
Publicado: F1000 Research Ltd 2017-11-01
Series:F1000Research
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Acceso en liña:https://f1000research.com/articles/6-2055/v1
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