Tussilagone Inhibits Osteoclastogenesis and Periprosthetic Osteolysis by Suppressing the NF-κB and P38 MAPK Signaling Pathways

BackgroundAseptic prosthetic loosening is one of the main factors causing poor prognosis of limb function after joint replacement and requires troublesome revisional surgery. It is featured by wear particle-induced periprosthetic osteolysis mediated by excessive osteoclasts activated in inflammatory...

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Bibliographic Details
Main Authors: Xuantao Hu, Ziqing Yin, Xia Chen, Guangyao Jiang, Daishui Yang, Ziqin Cao, Shuai Li, Zicheng Liu, Dan Peng, Pengcheng Dou
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
tussilagone
osteoclast
NF-κB
p38
MAPK
aseptic prosthetic loosening
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00385/full
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