Combinations of immuno-checkpoint inhibitors predictive biomarkers only marginally improve their individual accuracy

Abstract Background There are no accepted universal biomarkers capable to accurately predict response to immuno-checkpoint inhibitors (ICI). Although recent literature has been flooded with studies on ICI predictive biomarkers, available data show that currently approved companion diagnostics either...

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Detalhes bibliográficos
Main Authors: Matteo Pallocca, Davide Angeli, Fabio Palombo, Francesca Sperati, Michele Milella, Frauke Goeman, Francesca De Nicola, Maurizio Fanciulli, Paola Nisticò, Concetta Quintarelli, Gennaro Ciliberto
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-04-01
Colecção:Journal of Translational Medicine
Assuntos:
Immuno-checkpoint inhibitors biomarkers
Genomics
Immunotherapy
ImmunoPhenoScore
TIDE
RNA-seq
Acesso em linha:http://link.springer.com/article/10.1186/s12967-019-1865-8
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