SAAMBE-3D: Predicting Effect of Mutations on Protein–Protein Interactions

Maintaining wild type protein–protein interactions is essential for the normal function of cell and any mutation that alter their characteristics can cause disease. Therefore, the ability to correctly and quickly predict the effect of amino acid mutations is crucial for understanding disease effects...

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Hlavní autoři: Swagata Pahari, Gen Li, Adithya Krishna Murthy, Siqi Liang, Robert Fragoza, Haiyuan Yu, Emil Alexov
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2020-04-01
Edice:International Journal of Molecular Sciences
Témata:
protein–protein binding
machine learning
stabilizing and destabilizing mutation
disruptive and non-disruptive mutation
On-line přístup:https://www.mdpi.com/1422-0067/21/7/2563
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