SAAMBE-3D: Predicting Effect of Mutations on Protein–Protein Interactions

Maintaining wild type protein–protein interactions is essential for the normal function of cell and any mutation that alter their characteristics can cause disease. Therefore, the ability to correctly and quickly predict the effect of amino acid mutations is crucial for understanding disease effects...

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Main Authors: Swagata Pahari, Gen Li, Adithya Krishna Murthy, Siqi Liang, Robert Fragoza, Haiyuan Yu, Emil Alexov
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2020-04-01
Serija:International Journal of Molecular Sciences
Teme:
protein–protein binding
machine learning
stabilizing and destabilizing mutation
disruptive and non-disruptive mutation
Online dostop:https://www.mdpi.com/1422-0067/21/7/2563
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