CpxA Phosphatase Inhibitor Activates CpxRA and Is a Potential Treatment for Uropathogenic Escherichia coli in a Murine Model of Infection

ABSTRACT CpxRA is an envelope stress response system that is highly conserved in the Enterobacteriaceae. CpxA has kinase activity for CpxR and phosphatase activity for phospho-CpxR (CpxR-P), a transcription factor. In response to membrane stress, CpxR-P is produced and upregulates genes involved in...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Kate R. Fortney, Sara N. Smith, Julia J. van Rensburg, Julie A. Brothwell, Jessi J. Gardner, Barry P. Katz, Nagib Ahsan, Adam S. Duerfeldt, Harry L. T. Mobley, Stanley M. Spinola
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2022-04-01
Reeks:Microbiology Spectrum
Onderwerpen:
Escherichia coli
UPEC
CpxRA
phosphatase inhibitor
treatment
Online toegang:https://journals.asm.org/doi/10.1128/spectrum.02430-21
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items