Mesenchymal stromal cells from myelodysplastic and acute myeloid leukemia patients display in vitro reduced proliferative potential and similar capacity to support leukemia cell survival

Abstract Background Mesenchymal stromal cells (MSCs) are an essential element of the bone marrow (BM) microenvironment, playing a crucial function in regulating hematopoietic stem cell proliferation and differentiation. Recent findings have outlined a putative role for MSCs in hematological malignan...

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Hlavní autoři: Giulia Corradi, Carmen Baldazzi, Darina Očadlíková, Giovanni Marconi, Sarah Parisi, Nicoletta Testoni, Carlo Finelli, Michele Cavo, Antonio Curti, Marilena Ciciarello
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2018-10-01
Edice:Stem Cell Research & Therapy
Témata:
Mesenchymal stromal cells
Acute myeloid leukemia
Myelodysplastic syndrome
Leukemic microenvironment
On-line přístup:http://link.springer.com/article/10.1186/s13287-018-1013-z
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