Integrin Crosstalk and Its Effect on the Biological Functions of the Trabecular Meshwork/Schlemm’s Canal

Integrins are a family of heterodimeric receptors composed of an α- and β-subunit that mediate cell-adhesion to a number of extracellular matrix (ECM) proteins in the Trabecular Meshwork/Schlemm’s canal (TM/SC) of the eye. Upon binding an ECM ligand, integrins transmit signals that activate a number...

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Autori principali: Jennifer A. Faralli, Mark S. Filla, Donna M. Peters
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-04-01
Serie:Frontiers in Cell and Developmental Biology
Soggetti:
trabecular meshwork
glaucoma
integrin
extracelluar matix
crosstalk
Accesso online:https://www.frontiersin.org/articles/10.3389/fcell.2022.886702/full
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