Activation of αvβ3 Integrin Alters Fibronectin Fibril Formation in Human Trabecular Meshwork Cells in a ROCK-Independent Manner

PURPOSE: Fibronectin fibrillogenesis is an integrin-mediated process that may contribute to the pathogenesis of primary open-angle glaucoma (POAG). Here, we examined the effects of αvβ3 integrins on fibrillogenesis in immortalized TM-1 cells and human trabecular meshwork (HTM) cells. METHODS: TM-1 c...

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Bibliographic Details
Published in:Invest Ophthalmol Vis Sci
Main Authors: Filla, Mark S., Faralli, Jennifer A., Desikan, Harini, Peotter, Jennifer L., Wannow, Abigail C., Peters, Donna M.
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2019
Subjects:
Glaucoma
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750892/
https://ncbi.nlm.nih.gov/pubmed/31529121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.19-27171
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