Modulation of Mismatch Repair and the SOCS1/p53 Axis by microRNA-155 in the Colon of Patients with Primary Sclerosing Cholangitis

Deficient mismatch repair (MMR) proteins may lead to DNA damage and microsatellite instability. Primary sclerosing cholangitis (PSC) is a risk factor for colitis-associated colon cancer. MiR-155 is suggested to act as a key regulating node, linking inflammation and tumorigenesis. However, its involv...

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Main Authors: Monika Adamowicz, Iga Stukan, Piotr Milkiewicz, Andrzej Bialek, Malgorzata Milkiewicz, Agnieszka Kempinska-Podhorodecka
格式: Artigo
語言:Inglês
出版: MDPI AG 2022-04-01
叢編:International Journal of Molecular Sciences
主題:
miR-155
biomarker
microsatellite instability
inflammation
primary sclerosing cholangitis
colorectal cancer
在線閱讀:https://www.mdpi.com/1422-0067/23/9/4905
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