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Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors
Summary: Loss of heterozygosity (LOH) of the adenomatous polyposis coli (APC) gene triggers a series of molecular events leading to intestinal adenomagenesis. Haploinsufficiency of the cohesin Rad21 influences multiple initiating events in colorectal cancer (CRC). We identify Rad21 as a gatekeeper o...
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Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Artigo |
Lenguaje: | Inglês |
Publicado: |
Elsevier
2014-12-01
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Colección: | Cell Reports |
Acceso en línea: | http://www.sciencedirect.com/science/article/pii/S2211124714009280 |
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