Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

Summary: Loss of heterozygosity (LOH) of the adenomatous polyposis coli (APC) gene triggers a series of molecular events leading to intestinal adenomagenesis. Haploinsufficiency of the cohesin Rad21 influences multiple initiating events in colorectal cancer (CRC). We identify Rad21 as a gatekeeper o...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Huiling Xu, Yuqian Yan, Siddhartha Deb, Danny Rangasamy, Markus Germann, Jordane Malaterre, Noreen C. Eder, Robyn L. Ward, Nicholas J. Hawkins, Richard W. Tothill, Long Chen, Neil J. Mortensen, Stephen B. Fox, Michael J. McKay, Robert G. Ramsay
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Elsevier 2014-12-01
श्रृंखला:Cell Reports
ऑनलाइन पहुंच:http://www.sciencedirect.com/science/article/pii/S2211124714009280
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन