Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

Summary: Loss of heterozygosity (LOH) of the adenomatous polyposis coli (APC) gene triggers a series of molecular events leading to intestinal adenomagenesis. Haploinsufficiency of the cohesin Rad21 influences multiple initiating events in colorectal cancer (CRC). We identify Rad21 as a gatekeeper o...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Huiling Xu, Yuqian Yan, Siddhartha Deb, Danny Rangasamy, Markus Germann, Jordane Malaterre, Noreen C. Eder, Robyn L. Ward, Nicholas J. Hawkins, Richard W. Tothill, Long Chen, Neil J. Mortensen, Stephen B. Fox, Michael J. McKay, Robert G. Ramsay
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2014-12-01
Serier:Cell Reports
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124714009280
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker