Statistical methods for detecting differentially methylated loci and regions

DNA methylation, the reversible addition of methyl groups at CpG dinucleotides, represents an important regulatory layer associated with gene expression. Changed methylation status has been noted across diverse pathological states, including cancer. The rapid development and uptake of microarrays...

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Detalhes bibliográficos
Main Authors: Mark D Robinson, Abdullah eKahraman, Charity W Law, Helen eLindsay, Malgorzata eNowicka, Lukas M Weber, Xiaobei eZhou
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014-09-01
Colecção:Frontiers in Genetics
Assuntos:
DNA Methylation
Epigenomics
Genetics
statistics
bioinformatic tools and databases
differentially methylated regions
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00324/full
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