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Isoform prefiltering improves performance of count-based methods for analysis of differential transcript usage

BACKGROUND: RNA-seq has been a boon to the quantitative analysis of transcriptomes. A notable application is the detection of changes in transcript usage between experimental conditions. For example, discovery of pathological alternative splicing may allow the development of new treatments or better...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Soneson, Charlotte, Matthes, Katarina L., Nowicka, Malgorzata, Law, Charity W., Robinson, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729156/
https://ncbi.nlm.nih.gov/pubmed/26813113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0862-3
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