An Anti-PCSK9 Antibody Reduces LDL-Cholesterol On Top Of A Statin And Suppresses Hepatocyte SREBP-Regulated Genes

<p>Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for treating coronary heart disease. We report a novel antibody 1B20 that binds to PCSK9 with sub-nanomolar affinity and antagonizes PCSK9 function <i>in-vitro</i>. In CETP/LDLR-hemi mice two...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखक: Liwen Zhang, Timothy McCabe, Jon H. Condra, Yan G. Ni, Laurence B. Peterson, Weirong Wang, Alison M. Strack, Fubao Wang, Shilpa Pandit, Holly Hammond, Dana Wood, Dale Lewis, Ray Rosa, Vivienne Mendoza, Anne Marie Cumiskey, Douglas G. Johns, Barbara C. Han
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Ivyspring International Publisher 2012-01-01
श्रृंखला:International Journal of Biological Sciences
ऑनलाइन पहुंच:http://www.biolsci.org/v08p0310.htm
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