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An Anti-PCSK9 Antibody Reduces LDL-Cholesterol On Top Of A Statin And Suppresses Hepatocyte SREBP-Regulated Genes
<p>Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for treating coronary heart disease. We report a novel antibody 1B20 that binds to PCSK9 with sub-nanomolar affinity and antagonizes PCSK9 function <i>in-vitro</i>. In CETP/LDLR-hemi mice two...
Wedi'i Gadw mewn:
Prif Awdur: | |
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Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
Ivyspring International Publisher
2012-01-01
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Cyfres: | International Journal of Biological Sciences |
Mynediad Ar-lein: | http://www.biolsci.org/v08p0310.htm |
Tagiau: |
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