A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway

Abstract Background Long noncoding RNAs (lncRNAs) are recently found to be critical regulators of the epigenome. However, our knowledge of their role in osteoarthritis (OA) development is limited. This study investigates the mechanism by which HOTAIR, a key lncRNA with elevated expression in OA, aff...

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Autores principales: Yang Yang, Dan Xing, Yawei Wang, Haobo Jia, Bing Li, Jiao Jiao Li
Formato: Artigo
Lenguaje:Inglês
Publicado: BMC 2020-07-01
Colección:BMC Molecular and Cell Biology
Materias:
Osteoarthritis
Chondrocytes
Long noncoding RNA
HOTAIR
WIF-1
Wnt/β-catenin pathway
Acceso en línea:http://link.springer.com/article/10.1186/s12860-020-00299-6
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