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A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway

Abstract Background Long noncoding RNAs (lncRNAs) are recently found to be critical regulators of the epigenome. However, our knowledge of their role in osteoarthritis (OA) development is limited. This study investigates the mechanism by which HOTAIR, a key lncRNA with elevated expression in OA, aff...

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Main Authors: Yang Yang, Dan Xing, Yawei Wang, Haobo Jia, Bing Li, Jiao Jiao Li
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMC 2020-07-01
Sraith:BMC Molecular and Cell Biology
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Rochtain Ar Líne:http://link.springer.com/article/10.1186/s12860-020-00299-6
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