Revisiting NO<sub>2</sub> as Protecting Group of Arginine in Solid-Phase Peptide Synthesis

The protection of side-chain arginine in solid-phase peptide synthesis requires attention since current protecting groups have several drawbacks. Herein, the NO<sub>2</sub> group, which is scarcely used, has been revisited. This work shows that it prevents the formation of δ-lactam, the...

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Autori principali: Mahama Alhassan, Ashish Kumar, John Lopez, Fernando Albericio, Beatriz G. de la Torre
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2020-06-01
Serie:International Journal of Molecular Sciences
Soggetti:
δ-lactam formation
microwave
NBP
orthogonal protection
protecting group
sonochemistry
Accesso online:https://www.mdpi.com/1422-0067/21/12/4464
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