Immunizations with hepatitis B viral antigens and a TLR7/8 agonist adjuvant induce antigen-specific immune responses in HBV-transgenic mice

Background: The capacity of toll-like receptor (TLR) 7/8 agonist-conjugated hepatitis B virus (HBV) proteins (HBV-Ag) to overcome established hepatitis B surface antigen (HBsAg)-specific immune tolerance was explored. Methods: A TLR7/8 agonist, CL097, was conjugated with alum-absorbed HBsAg and hepa...

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Detalhes bibliográficos
Main Authors: Ying Wang, Kun Chen, Zhiyuan Wu, Yuetao Liu, Shangmei Liu, Zhongmei Zou, Shu-Hsia Chen, Chunfeng Qu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014-12-01
Colecção:International Journal of Infectious Diseases
Assuntos:
Toll-like receptor 7/8 agonists
Antigen-specific Th1 responses
Immune tolerant state
Chronic hepatitis B virus infection
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1201971214016002
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