MgrB-Dependent Colistin Resistance in Klebsiella pneumoniae Is Associated with an Increase in Host-to-Host Transmission

ABSTRACT Due to its high transmissibility, Klebsiella pneumoniae is one of the leading causes of nosocomial infections. Here, we studied the biological cost of colistin resistance, an antibiotic of last resort, in this opportunistic pathogen using a murine model of gut colonization and transmission....

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Bibliographic Details
Main Authors: Andrew S. Bray, Richard D. Smith, Andrew W. Hudson, Giovanna E. Hernandez, Taylor M. Young, Hannah E. George, Robert K. Ernst, M. Ammar Zafar
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2022-04-01
Series:mBio
Subjects:
antimicrobial peptides
gastrointestinal infection
host-to-host transmission
infection control
stress adaptation
two-component regulatory systems
Online Access:https://journals.asm.org/doi/10.1128/mbio.03595-21
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